Based on adverse drug-reaction (ADR) reports by 11 Canadian patients, the review concluded that "the risk of serious muscle-related side effects with the use of . Bottom Line. Creatine Monohydrate . Additionally, higher creatine levels or taking creatine without food seem to increase the chances of side effects. Publication types Case Reports MeSH terms Adult Alopecia / drug therapy Biomarkers / analysis 299. This is why guys need to know that Creatine may jack up their DHT levels fast. It is created by eHealthMe based on reports of 896 people who take Finasteride and Sertraline from the FDA, and is updated regularly. METHODS: We investigated the morphological changes in the prostate gland and the changes in the hormonal environment after administration of finasteride and arimidex to intact canine specimens. The whole cause of baldness was a study done on small sample size and now people who haven't got a clue how studies work have run with it. Creatine; Boron; Butea Superba; Caffeine; Tribulus Terrestris; 11-keto DHT; . lack of mental concentration. . However, as indicated by recent studies on . Reason being, finasteride is of course a pharmaceutical DHT inhibitor. Creatine is great for the gym. To start with, DHT is already present in your body naturally. So I started taking creatine a month ago and when I read more about it I learned that It causes hair loss and I am already balding. Very interesting, from this article it looks as if it's safe to supplement with Creatine. Results: Serum urea and creatinine levels were increased in both the finasteride and the dutasteride groups compared with those in the control group. The long-term effect of doxazosin, finasteride, and combination therapy on the clinical progression of benign prostatic hyperplasia. Creatine kinase was significantly increased by the high and low doses, whereas glucose was significantly decreased by both doses. 4. My question is if I take creatine for my workouts, would the Finasteride be able to offset this increase so that it won't result in increased shedding? In patients with chronic renal impairment, with creatinine clearances ranging from 9.0 to 55 mL/min, AUC, maximum plasma concentration, half-life, and protein binding after a single dose of 14 C-finasteride were similar to values obtained in healthy volunteers. As far as creatine causing hair loss in general, the data isn't the best from what I can tell. I remember there was a sudy showing creatine raising DHT from 40-60% after only a week of use. The meta-study examined 12 research papers that all . My Muscle Building Experience with Finasteride, Fat Loss, Gynecomastia and Gaining Strength! 1. Finasteride causes cognitive & sexual decline. Zinc supplementation (120mg twice daily) significantly increased DHT (19%), and also slightly increased testosterone in eugonadal men (490 to 750ng/dl), showing upregulation of the 5 alpha reductase enzyme even at very high dose zinc ( R ). 349(25):2387-98. 15. Joined Nov 9, 2020 Posts 1,803 Reputation 2,602 Time online 53d 3h 52m. insomnia. Fact or Myth: Do Creatine Supplements Cause Hair Loss? I have gone from 90kg 25+%BF to at my most cut 76kg 15% BF. Finasteride tablets USP, are indicated for the treatment of symptomatic benign prostatic hyperplasia (BPH) in men with an enlarged prostate to: -Improve symptoms -Reduce the risk of the need for surgery including transurethral resection of the prostate (TURP) and prostatectomy. . 5-AR inhibitors like finasteride or dutasteride are the most common (and likely effective) hair loss treatments because they stop the conversion process. Finasteride and dutasteride induce liver lipid accumulation and steatosis. Trusted Source. It's H.C.G (HCG) dosed at 250IU Monday, Wednesday and Friday only. So you're fine to take the two together - everyone gets creatine in daily from meat etc, you're just getting a fair bit more through direct supplementation. . Histopathological analysis and DNA damage assays showed that finasteride has adverse effects within both the short and the long periods in female mice. So finasteride inhibits two 5-alpha reductase isoenzymes (types II and III). Urinary excretion of metabolites was decreased in patients with renal impairment. However, in the finasteride-treated rats; creatine (55.7 12.3 % of control group) and lactate (133.8 19.5 % of control group) levels were significantly closer to those in the normal group rats compared to the placebo group (p < 0.05 each) . Thread starter Joined Feb 26, 2018 Messages 4,275 . The treatment of benign prostatic hyperplasia with 5 mg of finasteride per day results in a significant decrease in symptoms of obstruction, an increase in urinary flow, and a decrease in . Furthermore, finasteride inhibits CYP3A4 (which is the enzymes that detox finasteride) and that can cause a significant buildup of finasteride in the body . Finasteride causes cognitive & sexual decline. Reporting hair sheds from creatine has little scientific credibility. As well as causing alterations in the brain, Flomax can have many other adverse effects. (pain in muscles with breakdown of muscle tissue and an increase in certain muscle proteins known as creatine kinase [CK] enzymes, myopathy . The notion of 'creatine baldness' began in 2009, with a study published in the Clinical Journal of Sports Medicine. 5AR1 is found mainly in the brain, muscle, liver, and sebaceous glands. Creatine is not recommended for people with kidney disease or those with kidney problems. The study consisted of four groups: a 5-alpha-reductase only group (5RI only, n = 5); a 5RI plus aromatase-inhibitor combination group (5RI + ARI . 1 Previous finasteride, dutasteride, bicalutamide are allowed at PI discretion. Common interactions include aortic arteriosclerosis among females and death among males. Assuming that creatine use did cause your hair to thin, it should start to grow back since you stopped intake. . You can read more on zinc here . Further, the creatine and lactate levels in corpus striatum in MRS, the neuronal counts and glial activity of the hippocampus and cerebellum were closer to the control group in the finasteride-treated group compared to the placebo group. The primary side effects appeared to be related to gastrointestinal symptoms. . Conclusion: Reversible myalgia associated with significant hyperCKemia is a possible adverse reaction of finasteride therapy. [Medline] . The extent to which this side effect is dose-dependent has not been determined. Discussion Creatine and Finasteride OP Pretty_bread; Start date Jan 26, 2021; Pretty_bread Adept. It's sold under the brand names Propecia and Proscar. An article suggests that "Creatine administration is known to decrease the consumption of S-adenosyl methionine and also reduce the homocysteine production in liver, . The elimination half-life of creatine is approximately 3 hours, indicating that 50% of a dose will be cleared from your plasma at roughly 3 hours post-ingestion. It is commonly used in the treatment of prostate cancer, benign prostatic hyperplasia (BPH), and androgenic alopecia (AGA) [3,4,5]. The phase IV clinical study analyzes what interactions people who take Finasteride and Sertraline have. A 2014 meta-study coined the phrase " Post Finasteride Syndrome, "and noted that "Many clinicians are unaware of the scope of the persistent physical and psychological adverse effects of finasteride. If you took away 5-AR from these tissues and blocked the formation of DHT, then you would see some dramatic changes in physiology. If you're already taking finasteride and use creatine as a dietary supplement then the odds of it having an impact on your hair loss I would assume are extremely slim. Finasteride, Super Bio-Curcumin, Theaflavins, Soy Isoflavones , Flax Lignans, Coconut Oil, etc) that have been shown to lower dht and and/or inhibit its binding to receptor . A lot of people are under the misconception that since finasteride doesn't inhibit type 1 (which is found in the . Dowman et al [] reported that 5-Rs types 1 and 2 are highly expressed in human liver and inhibition of these enzymes may elicit adverse metabolic consequences.In the animal model, inhibition of 5-Rs types 1 and 2 impeded glucocorticoids and androgens metabolism and contributed to the pathogenesis of nonalcoholic . I'm on Finasteride and Nizoral only.. Finasteride 1mg temporarily reverses hair loss in men with androgenetic alopecia (male pattern baldness). Answer: Finasteride with Creatine There should be no problem using both of these together. In 2 studies of healthy subjects (n=69) receiving PROSCAR 5 mg/day for 6-24 weeks, finasteride . However, if the creatine has accelerated an existing propensity to a genetic condition, whilst your hair loss may slow down again now you are no longer taking the supplement, the lost hair may not come back without regrowth treatment . insomnia. Creatine and finasteride (DHT blocker) Hi everyone. While both creatine and whey protein promote muscle gain, they differ in the ways they work. As compared to women, men have higher levels of DHT, and it plays a part [] in the development of manly attributes like stronger bones, higher strength, deeper voices, increased muscle mass, etc.Hence, akin to other hormones, DHT [] is not intrinsically "bad" or "good." After nearly 4 years of suffering, I have finally & fully recovered from Post Finasteride Syndrome. This recent finasteride label change comes one year after Health Canada's safety review of the drug, which assessed the potential risks of serious muscle-related side effects. All my symptoms have subsided and improved with this method which takes a while but I am fully functional. A 30-year-old man who had been taking finasteride 5 mg/d for 10 years to treat frontal baldness developed diffuse muscle aches associated with elevated creatine kinase level to 10,117 IU/L with . I'm currently on Finasteride.been so for about 4 months. 3) Cephalosporin antibiotics. Mar 3, 2017. When you take creatine. It works by decreasing the amount of a natural body hormone (DHT), which causes your prostate to grow larger. You see, DHT is a much stronger androgen than testosteroneit binds about 3-5 times more strongly to the androgen receptor. But it can cause significant hair loss/ thinning after few months. I've been taking creatine monohydrate and finasteride daily for years. The most common side effect of creatine supplementation is water retention leading to weight gain, but other possible side effects include: muscle cramps, nausea, dizziness, stomach problems, dehydration and heat intolerance. londonhairlossvictim Members 228 Examples of oral cephalosporins include cephalexin (Keflex), cefuroxime (Ceftin) and . So.. if finasteride lowers DHT by 65%.. you're good. Dutasteride is probably more harmful than finasteride, as dutasteride inhibits all isoforms of the 5a reductase enzyme and finasteride mostly focuses on 5a reductase type 2 (but also inhibits the other ones). While some hail it as a useful tool to increase muscle gains, boost recovery, and . 5-alpha-reductase is an enzyme that converts testosterone into DHT. The drug itself works directly on your body's conversion mechanism that makes testosterone to dht. Finasteride is a 5-alpha reductase inhibitor that's used to treat androgenetic alopecia (a clinical term for male pattern baldness) and benign prostatic hyperplasia (non-cancerous growth of the prostate gland). There isn't a problem/contraindication in taking creatine with finasteride specifically, no. quakociaptockh depressed subhuman autistic hiinhib oldcel midget. Finasteride led significant improvement in autism-like behavioral parameters. #1. Two necessary things for sex. Creatine may be somewhat helpful as well. Use 5 grams per day, every day, for the . A 2014 meta-study coined the phrase " Post Finasteride Syndrome, "and noted that "Many clinicians are unaware of the scope of the persistent physical and psychological adverse effects of finasteride. Flecainide, Pravastatin, and Finasteride. In the present study, finasteride is seen to have caused DNA damage and menstrual bleeding in women who used . The meta-study examined 12 research papers that all . It is also available as a generic drug. After inducing euthanasia, blood was collected for urea and creatinine analyses, and both the kidneys were collected for stereological analyses of kidney morphology. The intake of creatine supplements is popular among athletes and bodybuilders. lol. Several commonly used chemotherapy drugs such as cisplatin, carboplatin, methotrexate and mitomycin can cause creatinine increases. Anyway, I think I've just hit my first (noticeable) shed at about the 13 month mark, and it has got me thinking. - - - - - - - - - - - - - - - - - - - - -. PRP, transplant, minoxidil, biotin, etc can help to regrow the lost hair . His symptoms resolved and his creatine kinase level dropped down to 256 IU/L 3 weeks after finasteride discontinuation. Here's what I learned! . Combination with Alpha-Blocker depression. It cites 13 studies done looking at the affects of creatine on testosterone, free testosterone, and DHT. This can be broken down later during physical activity to be used as energy for muscle contractions. Creatine is placebo tbh . Just like creatine, Biotin is naturally produced by the human body, and has been proven to aid hair growth . With this information we can calculate that 100% of exogenously administered creatine should be out of your system within 16.5 hours of your final dose. Creatine has also been shown to not only reduce muscle breakdown but also increases the amount of water in muscle cells which results in quicker muscle growth. Health Canada reviewed the risk of potential serious muscle-related side effects with finasteride use because of reports in which these events were seen in patients treated with Propecia and Proscar. loss of libido, penile shrinkage. N Engl J Med . Finasteride binds to 5-R type 2 with high affinity and dissociates very slowly with a half-life of 31 days. A patent filed for a creatine supplement cited research that found that side effects occurred for 25% of females and 38% of males taking creatine. Finasteride is a steroidal inhibitor of 5-reductase type 2 (5-red2), which prevents irreversible reduction of T (testosterone) into DHT (dihydrotestosterone) [1,2]. . Finasteride CLINICAL USE Benign prostatic hypertrophy Male pattern baldness DOSE IN NORMAL RENAL FUNCTION BPH: 5 mg dailyMale pattern baldness: 1 mg daily PHARMACOKINETICS ; Molecular weight :372.5 %Protein binding :93 %Excreted unchanged in urine : 0.05 It binds and . Finasteride 5mg tablets (brand name Proscar) are indicated for the treatment of symptomatic BPH in men with an enlarged prostate. 5AR2 can be found in the prostate, seminal vesicles, liver and hair follicles. I do recommend whey protein shake (special formulation for hair loss) to my patients who work out to help block androgen uptake in the scalp. Download : Download high-res image (156KB) Download : Download full-size image I understand there is some evidence that demonstrated creatine increases DHT. Symptoms range from minor to severe.". Joined May 16, 2020 Posts 132 Reputation 141 Time online 8d 13h 9m. In my opinion it's massively helped me recomp. Watch this video that explains it better than I can. By Neel Duggal, October 1, 2021. Do any of these meds cause a problem with glaucoma? His measured creatine phosphokinase (CPK) is over 35,000 IU/liter. This also occurs with heavy-duty antibiotics such as amphotericin A that are used as chemotherapeutic agents. B Bad Established Member Reaction score 14 Nov 20, 2014 #9 xRedStaRx said: I don't think of anything.